Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1
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منابع مشابه
Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1
[This corrects the article DOI: 10.1371/journal.pbio.1002243.].
متن کاملInsulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1
Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. PGK1 plays a key role in coordinating glycolytic energy production with one-carbon metabolism, serine biosynthesis, and cellular redox regulation. Here, we report that PGK1 is acetylated at lysine 220 (K220), which...
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In the ancient metabolic pathway of glycolysis, phosphoglycerate kinase 1 (PGK1) plays a pivotal role. After a couple of preliminary steps that prime the pump, it is PGK1 that creates the first molecule of ATP from the energy stored in glucose, by swinging a molecule of ADP in close to pick a phosphate off an energetic intermediate. While much is known about transcriptional control of PGK1, rel...
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Platelet activation and thrombus formation are under the control of signaling systems that integrate cellular homeostasis with cytoskeletal dynamics. Here, we identify a role for the ribosome protein S6 kinase (S6K1) and its upstream regulator mTOR in the control of platelet activation and aggregate formation under shear flow. Platelet engagement of fibrinogen initiated a signaling cascade that...
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ژورنال
عنوان ژورنال: PLOS Biology
سال: 2015
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1002287